benzene aplastic anemia

Benzene BZ is an important occupational and environmental pollutant. Exposure to BZ may cause aplastic anemia which is characterized as bone marrow hematopoietic failure.

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Benzene exposures can cause aplastic anemia.

. The association between benzene exposure and bone marrow suppression has been recognized since 1897. Severe chronic benzene poisoning at doses 100 ppm is an established cause of aplastic anemia and leukemia. Toxic substances such as pesticides arsenic and benzene Radiation therapy and chemotherapy for cancer Certain medicines Infections such as hepatitis Epstein-Barr virus or HIV Autoimmune disorders Certain inherited conditions Pregnancy.

However the probability that these drugs will lead to aplastic anemia in a given patient is very low. Benzene exposure is now a negligible risk factor accounting. This chemical is naturally found in the environment as well as in many man-made products such as industrial solvents drugs plastics gasoline dyes synthetic rubber resins detergents and lubricants.

It is concluded this type of pancytopenia is primarly due to interference of benzene with DNA and RNA synthesis and not to a failure of the hemopoietic. Benzene used as a solvent in many industries is a known carcinogen which can lead to variety of hematological manifestations like macrocytic anemia aplastic anemia myelodysplasticsyndrome and leukemia. Aplastic anemia is also sometimes associated with exposure to toxins such as benzene or with the use of certain drugs including chloramphenicol carbamazepine felbamate phenytoin quinine and phenylbutazone.

This disease can lead to damaged bone marrow. Aplastic anemia can also lead to leukemia or myelodysplasia. In order to reduce the harmful effects of this pollutant it is necessary to identify additional preventative measures.

Aplastic anemia caused by bone marrow suppression is the classic cause of death in chronic benzene poisoning. The hematotoxicity of benzene is related to the amount and duration of exposure. Night sweats petechiae splenomegaly and pancytopenia.

Toxic chemicals such as some used in pesticides and insecticides and benzene an ingredient in gasoline have been linked to aplastic anemia. At high levels of benzene exposure air concentration 100 ppm the incidence of aplastic anaemia is approximately 1100 individuals exposed but this drops precipitously at lower levels of exposure 1020 ppm to around 110000. Exposure to BZ may cause aplastic anemia which is characterized as bone marrow hematopoietic failure.

These mainly involve aplastic anaemia the first cases of which were reported in 1897. Exposure to benzene a common chemical used widely in industry may progressively lead to pancytopenia aplastic anemia and leukemia. There are different types of aplastic anemia including Fanconi anemia.

Most risk predictions for benzene exposures have been based on rubber workers who were exposed to high concentrations. US attempt to control occupational exposure. However benzene induced aplastic anemia in diamond industry has not been reported so far in literature.

In order to reduce the harmful effects of this pollutant it is necessary to identify additional preventative measures. Thus benzene depresses the production of blood cells which can result in blood disease or cancer including aplastic anemia. Aplastic anemia is a rare condition that occurs when your body stops producing enough new blood cells.

Exposure to toxic chemicals. Aplastic anemia can be a temporary side effect of these treatments. Fatal aplastic anemia following benzene exposure was first reported in workers in the 19th century.

Benzene BZ is an important occupational and environmental pollutant. Aplastic anemia can lead to other health concerns such as an irregular heartbeat an enlarged heart and heart failure. According to the Agency for Toxic Substances Disease Registry a division of the Department of Health Human Services Benzene-induced aplastic anemia is caused by chronic exposure at relatively high doses Fatal aplastic anemia following benzene exposure was first reported in workers in the 19th century.

This type of anemia might improve if you avoid repeated exposure to the chemicals that caused your illness. It can be caused by injury to blood stem cells due to exposure to certain drugs chemotherapy congenital disorders drug therapy to suppress the immune system pregnancy radiation therapy or toxins such as benzene or arsenic. Aplastic anemia is not categorized as a cancer but can be just as serious.

Although the mechanisms by which benzene causes toxicity remain to be fully elucidated it is widely accepted that its metabolism is crucial to its toxicity with involvement of one or more reactive metabolites. Benzene is a colorless and sweet smelling chemical that has been directly related to a portion of the aplastic anemia cases. A painter who was exposed to benzene for 13 years developed a hypocellular bone marrow and pancytopenia.

Recent research by the National Cancer Institute conducted in China has shown that even low-level benzene exposure can cause a decrease in blood cells including white blood cells lymphocytes B cells and platelets. States in his article titled Benzene as a Leukemogenic and Carcinogenic Agent Amer. During the 15 years after recovery from aplastic anemia there were found in the peripheral blood leukopenia thrombocytopenia and anemia.

89-20 1985 Although the use of benzene started around the second half of 19th century the chronic toxic effect of this chemical agent was. Autoradiographic studies on bone marrow cells of rabbits with benzene induced oancytopenia revealed a severely disturbed DNA and RNA synthesis. Chronic exposure to benzene is known to cause aplastic anemia and increased risk of acute myelogenous leukemia in humans.

Also a high incidence of chromosome aberrations were demonstrated. Benzene also impairs hematopoiesis and industrial exposure to benzene figured prominently in the early literature on aplastic anemia. Until this time benzene was considered a cause of leukaemia based not upon epidemiological studies but rather upon case reports of leukaemia and the clinical observation that individuals with benzene-induced aplastic anaemia and other blood diseases transformed into acute leukaemia.

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